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KMID : 1039420160500030231
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Journal of Pathology and Translational Medicine
2016 Volume.50 No. 3 p.231 ~ p.237
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Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread
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Kim Na-Rae
Cho Hyun-Yee
Baek Jeong-Heum
Jeong Ju-Hyeon
Ha Seung-Yeon
Seok Jae-Yeon
Park Sung-Won
Sym Sun-Jin
Lee Kyu-Chan
Chung Dong-Hae
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Abstract
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A 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft tissue lesion in the right perianal area. Inguinal lymph node dissection and Mils’ operation extended to perianal and perivulvar skin was performed. Histologically, the anal canal lesion was composed of mucin-containing signet ring cells, which were similar to those found in Pagetoid skin lesions. It was diagnosed as an anal canal signet ring cell carcinoma (SRCC) with perianal and vulvar Pagetoid spread and bilateral inguinal lymph node metastasis. Anal canal SRCC is rare, and the current case is the third reported case in the English literature. Seven additional cases were retrieved from the world literature. Here, we describe this rare case of anal canal SRCC with perianal Pagetoid spread and provide a literature review.
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KEYWORD
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Carcinoma, signet ring cell, Anal canal, Paget disease, extramammary
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